Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated...
Gliomas are aggressive brain tumors and resistant to current standard and targeted therapeutic interventions...
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Key Publications
Parmigiani, E. Giachino, C. Taylor, V.
- Oct 14, 2020
Oncogenic and Tumor-Suppressive Functions of NOTCH Signaling in Glioma
Paper URL: MDPI Although the role of NOTCH signaling has been extensively studied in health and disease, many questions still remain...
119 views
Mukhtar, T. Breda, J. Grison, A. Karimaddini, Z. Grobecker, P. Iber, D. Beisel, C. van Nimwegen E. & Taylor, V.
- Mar 13, 2020
Tead transcription factors differentially regulate cortical development
Paper URL: Nature Neural stem cells (NSCs) generate neurons of the cerebral cortex with distinct morphologies and functions. How specific...
149 views
Zhang, R. Boareto, M. Engler, A. Louvi, A. Giachino, C. Iber, D. & Taylor, V.
- Aug 6, 2019
Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus
Paper URL: Science Direct Neural stem cells (NSCs) in the adult mouse hippocampal dentate gyrus (DG) are mostly quiescent, and only a few...
97 views
Engler A, Zhang R, and Taylor V.
- Jul 19, 2018
Notch and Neurogenesis
Paper URL: Springer Neurogenesis is the process of forming neurons and is essential during vertebrate development to produce most of the...
36 views
Vogt MA, Ehsaei Z, Knuckles P, Higginbottom A, Helmbrecht MS, Kunath T, Eggan K, Williams LA, Shaw PJ, Wurst W, Floss T, Huber AB, Taylor V.
- May 25, 2018
TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons
Paper URL: Scientific Report TAR DNA-binding protein 43 (TDP-43) is a key player in neurodegenerative diseases including frontotemporal...
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Mukhtar T, Taylor V.
- Mar 1, 2018
Untangling Cortical Complexity During Development
Paper URL: Sage Pub The cerebral cortex is composed of billions of morphologically and functionally distinct neurons. These neurons are...
196 views
Engler A, Rolando C, Giachino C, Saotome I, Erni A, Brien C, Zhang R, Zimber-Strobl U, Radtke F, Artavanis-Tsakonas S, Louvi A and, Taylor V
- Jan 23, 2018
Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone
Paper URL: Science Direct Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of the adult forebrain from quiescent...
38 views
Boareto M, Iber D, and Taylor V.
- Sep 30, 2017
Boareto, M. et al. Development
Paper URL: Development Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor...
18 views
Fedele S, Collo G, Behr K, Bischofberger J, Müller S, Kunath T, Christensen K, Gündner AL, Graf M, Jagasia R, Taylor V.
- Jul 19, 2017
Fedele, S. et al., Scientific Reports
Paper URL: Nature Expansion of human midbrain floor plate progenitors from induced pluripotent stem cells increases dopaminergic neuron...
34 views
Zhang R, Engler A, and Taylor V.
- Jun 15, 2017
Notch: an interactive player in neurogenesis and disease
Paper URL: Springer Notch signaling is evolutionarily conserved from Drosophila to human. It plays critical roles in neural stem cell...
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Rolando C, Erni A, Grison A, Beattie R, Engler A, Gokhale PJ, Milo M, Wegleiter T, Jessberger S, Taylor V.
- Nov 3, 2016
Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB
Paper URL: Science Direct Adult neural stem cells (NSCs) are defined by their inherent capacity to self-renew and give rise to neurons,...
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Giachino C,Boulay JL,Ivanek R,Alvarado A,Tostado C,Lugert S,Tchorz J,Coban M,Mariani L,Bettler B,Lathia J,Frank S,Pfister S,Kool M, Taylor V
- Dec 14, 2015
A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes
Paper URL: Science Direct In the brain, Notch signaling maintains normal neural stem cells, but also brain cancer stem cells, indicating...
27 views
Rolando, C., Taylor V.
- Oct 7, 2014
Neural stem cell of the hippocampus: development, physiology regulation, and dysfunction in disease
Paper URL: Science Direct The formation of the hippocampus is generated during embryonic development, but most neurons within the...
17 views
Giachino C, Taylor V
- Feb 25, 2014
Notching up neural stem cell homogeneity in homeostasis and disease
Paper URL: Frontiers in Neuroscience Adult neural stem cells (NSCs) are perceived as a homogeneous population of cells that divide...
9 views
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