Glioblastomas (GBMs, WHO grade 4 gliomas) are devastating brain tumors that are resistant to current therapeutic interventions. Diffuse infiltration and invasion of the healthy brain are hallmarks of GBM. Invasive GBM cells can home towards distinct niches in the tissue that serve as hubs for further spreading. GBMs are highly heterogeneous and even the invasive behavior of GBM cells is heterogeneous across tumors. However, it remains unclear how different invasion modes of distinct glioma subtypes are regulated at the molecular level. I aim to elucidate mechanisms underlying GBM invasion and differences between subtypes of the disease on the molecular level.