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Human embryonic brain development has not been well studied at a mechanistic level due to a number of ethical restraints. However, the advent of the organoid revolution enabling the study of organ self assembly in vitro has given scientists a tool and opportunity to study the development of many complex human organ systems. I plan to use neuronal organotypic culturing and cerebral organoids to model normal human brain development as well as brain development in several neurodevelopmental pathologies using patient derived iPSCs. Identifying developmental aberrations in the human brain leads us to better understand the brain as well as develop potential therapeutic strategies in the future.
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