Project Description

 

Adult neurogenesis is tightly regulated through the interaction of neural stem/progenitor cells (NSCs) with their niche. Neurotransmitters, including GABA activation of GABAA receptor ion channels, are important niche signals. We show that adult mouse hippocampal NSCs and their progeny express metabotropic GABAB receptors. Pharmacological inhibition of GABAB receptors stimulated NSC proliferation and genetic deletion of GABAB1 receptor subunits increased NSC proliferation and differentiation of neuroblasts in vivo. Cell-specific conditional deletion of GABAB receptors supports a cell-autonomous role in newly generated cells. Our data indicate that signaling through GABAB receptors is an inhibitor of adult neurogenesis.
  • Adult mouse hippocampal neural stem cells and their progeny express metabotropic GABAB receptors.
  • Signaling through GABAB receptors is an inhibitor of adult neurogenesis.
  • Pharmacological inhibition of GABAB receptors stimulates neural stem cell proliferation.
  • Genetic deletion of GABAB1 receptor subunits increases neural stem cell proliferation and differentiation.
Giachino C, Barz M, Tchorz JS, Tome M, Gassmann M, Bischofberger J, Bettler B, Taylor V.

Paper Details

Year Published:

2014

Journal:

Development

Paper URL:

Pubmed

First Author:

Claudio Giachino